Abstract Background The Chromomethylase 1 (CMT1) has long been considered a nonessential gene because, in certain Arabidopsis ecotypes, the GREEN TEA MOISTURIZER CMT1 gene is disrupted by the Evelknievel (EK) retroelement, inserted within exon 13, or contains frameshift mutations, resulting in a truncated, non-functional protein.In contrast to othe
Abstract Background Osteosarcoma is one of the most common malignant bone tumors with bad prognosis.Necroptosis is a form of programmed cell death.Recent studies showed that targeting necroptosis was a new promising approach for tumor therapy.This study aimed to establish a necroptosis-related gene signature to evaluated prognosis and explore the r
Abstract Background Bilateral cleft lip surgery is very challenging and requires a high level of skill, knowledge and experience.Existing high-fidelity simulation models that can be used by novice cleft surgeons to gain experience and expand their knowledge are rare and expensive.In this study, we developed a bilateral cleft lip model using porcine
JAK-STAT signaling pathway is an important cytokine signaling transduction pathway.Many monogenic loss-of-function or gain-of-function mutations in this pathway can cause inborn errors of immunity (IEI).Autoimmune diseases are caused by polygenic and different factors.The etiology of the disease is complex and Clip diverse.The over-activation of JA
The Mainz profile algorithm (MAPA) derives vertical profiles of aerosol extinction and trace gas concentrations from MAX-DOAS measurements of slant column densities under multiple elevation angles.This paper presents (a) a detailed description of the MAPA (v0.98), (b) results for the CINDI-2 campaign, and (c) sensitivity studies on the impact of a